GeriatricĪppropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of hydrocodone in the elderly. Safety and efficacy have not been established. For non-prescription products, read the label or package ingredients carefully.Īppropriate studies have not been performed on the relationship of age to the effects of hydrocodone in the pediatric population.
Hydrocodone white grapefruit juice professional#
Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.
For this medicine, the following should be considered: Allergies This is a decision you and your doctor will make. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This product is available in the following dosage forms: Hysingla® and Zohydro® are available only under a restricted distribution program called the Opioid Analgesic REMS (Risk Evaluation and Mitigation Strategy) program.
This medicine is available only with your doctor's prescription. However, severe withdrawal side effects can usually be prevented by gradually reducing the dose over a period of time before treatment is stopped completely. Physical dependence may lead to withdrawal side effects if treatment is stopped suddenly. Mental dependence (addiction) is not likely to occur when narcotics are used for this purpose. However, people who have continuing pain should not let the fear of dependence keep them from using narcotics to relieve their pain. When hydrocodone is used for a long time, it may become habit-forming, causing mental or physical dependence. It acts on the central nervous system (CNS) to relieve pain. Because acetaminophen is almost completely absorbed these effects seems to be related to increased elimination half-life of acetaminophen because of interaction with grapefruit juice.Hydrocodone belongs to the group of medicines called narcotic analgesics (pain medicines). In contrast, pink grapefruit juice increased acetaminophen concentrations 2 hours after feeding compared to controls. White grapefruit juice increased concentrations of acetaminophen in mice both 1 hour and 2 hours after feeding compared to controls. The concentrations of acetaminophen in sera of mice were determined by fluorescence polarization immunoassay.
Blood was withdrawn from the retro-orbital venous plexus at 1 hour and 2 hours after feeding with acetaminophen. BALB/c mice were fed 200 microL of white grapefruit juice or pink grapefruit juice by oral gavage (three mice in each group) followed by oral delivery of 10, 50, or 100 mg/kg acetaminophen 1 hour later. The interaction of grapefruit juice with acetaminophen was examined in an in vivo mouse model. However, interaction between acetaminophen (also known as paracetamol in many parts of the world) and grapefruit juice has never been reported. Grapefruit juice increases bioavailability of a number of drugs because of inhibition of the P-glycoprotein pump and inhibition of intestinal cytochrome P450 3A4 enzyme.
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